Description
The CoviDrop™ SARS-CoV-2 Targeted Proprotein Convertase Inhibitor Screening Fast Kit is a complete set of optimized buffers and reagents designed for screening inhibitors of SARS-CoV-2-specific proprotein convertase (PC) such as furin and other serine proteases that may also target the PC cleavage motif in SARS-CoV-2 in a fast and high throughput format.
- Fast: Colorimetric assay with easy-to-follow steps for convenience and speed. The entire procedure can be finished within 2 hours.
- Robust: Innovative kit composition enables background signals to be extremely low and allows the assay to be simple, accurate, reliable, and consistent.
- Sensitive: The activity can be detected from as low as 2 ng of PC (ex: furin) or facilitated serine protease (ex: HAT).
- Specific: The substrate contains the entire SARS-CoV-2 S1/S2 cleavage sequence and is proven to be the same as real spike protein with tertiary structure in PC cleavage tests. Thus, the assay is uniquely specific for detecting SARS-CoV-2 S1/S2 cleavage and is suitable for measuring inhibitory effects of various inhibitors against SARS-CoV-2-targeted cleavage PCs, including small molecule chemicals, therapeutic peptide, or other biological inhibitors.
- Flexible: Strip-well microplate format makes the assay flexible for manual or high throughput analysis.